Jimmy Garoppolo couldnt have a tougher assignment in his first NFL start. While Tom Brady is suspended, the third-year quarterback faces the Arizona Cardinals, one of the Super Bowl favorites, a team owning a strong defense.At Arizona.In prime time.Theres so much going on right now, Garoppolo said. Mentally, Im straight Arizona, but it is a phenomenal opportunity. This is why you play the game. You play to be in the game and play; you dont want to be the backup. The opportunity is here. Ive just got to go take advantage of it.That opportunity is thanks to the Deflategate saga that finally has played out. Brady is gone for four weeks, and Jimmy G is the guy.I think that just comes with being a quarterback, said of taking ownership of the position -- for now.Naturally, that kind of happens on its own. But yeah, you want to go in there and let the guys know that youre here to work and here to do your job the right way.Arizona is quite the challenge, with perhaps the most talented roster in the NFL. And back from injury is All-Pro safety Tyrann Mathieu, who adds spark and gumption to the defense.How did coach Bruce Arians know the Honey Badger was ready after the safety missed the preseason?Its about two interceptions every day, Arians said. He flies around and makes every check and has the energy and passion that he always has.Also Sunday, its Green Bay at Jacksonville, the New York Giants at Dallas, Minnesota at Tennessee, Miami at Seattle, San Diego at Kansas City, Oakland at New Orleans, Cincinnati at the New York Jets, Buffalo at Baltimore, Cleveland at Philadelphia, Chicago at Houston, Tampa Bay at Atlanta, and Detroit at Indianapolis.On Monday night, the doubleheader has Pittsburgh at Washington and the Rams -- yes, representing Los Angeles -- at San Francisco.The season kicked off Thursday night with Denvers 21-20 victory over Carolina in a rematch of the Broncos Super Bowl victory. Carolinas Graham Gano missed a 50-yard field goal with four seconds remaining.Green Bay at JacksonvilleIm playing football, Packers receiver Jordy Nelson said when asked if his knees were an issue as he comes off a torn right ACL in a preseason game last summer at Pittsburgh.Nelsons availability is a key for Green Bay, which ranked only 25th in passing a year ago despite having Aaron Rodgers.If the Jaguars rebuild is nearing completion, these are the kind of games they need to win. Or at the very least, be competitive.New York Giants at DallasTime to find out if all that optimism coming out of Dallas about Dak Prescott stepping in for injured quarterback Tony Romo is valid.Wouldnt have expected for it to happen this early, but it did unfortunately, Prescott said. For it to be a reality now, to be a starting quarterback, its fun just to get in the huddle and be around a bunch of great guys and get to play in this division.Its also time to find out if all those defensive changes the Giants made -- Olivier Vernon, Damon Harrison, Janoris Jenkins, Eli Apple -- warrant any enthusiasm for them and new coach Ben McAdoo.Minnesota at TennesseeMinnesota is another team without its starting QB -- Teddy Bridgewater wrecked his left knee in practice and is gone for the season. The Vikings dealt for Sam Bradford this week, but how soon he will be ready is a huge unknown.No such issues for the Titans with Marcus Mariota. How their running game with newcomers DeMarco Murray and Derrick Henry performs against Minnesotas stout defense could be telling.Pittsburgh at Washington, Monday nightWithout LeVeon Bell in the backfield and Martavis Bryant at receiver (both suspended), the Steelers would appear undermanned. They still have Ben Roethlisberger throwing to Antonio Brown, though, and veteran DeAngelo Williams was a terrific stand-in last year for Bell.The Redskins added All-Pro Josh Norman at cornerback to bolster a D that ranked 25th against the pass. They also need to figure out their running game.Miami at SeattleAdam Gase made his reputation as a QB guru while working with Peyton Manning in Denver. He now is in charge of the Dolphins, and Ryan Tannehill is no Manning.Even worse, the Seahawks seem to be on a mission, with a nasty defense, productive offense and everything in place for another Super Bowl run -- if their offensive line coalesces.San Diego at Kansas CityHow predictable was this: Chargers top draft pick Joey Bosa has a damaged leg after missing all of preseason in a holdout. The defensive end likely wont suit up.Kansas City also will be minus some key players, including star linebacker Justin Houston and running back Jamaal Charles. Coach Andy Reid said its a stretch to expect Charles to suit up.Oakland at New OrleansDrew Brees reworked his contract. Now if only the Saints can rework a defense that ranked 31st across the board on the yardage charts in 2015. The hope in the Big Easy is that linebacker James Laurinaitis can spark an already banged-up unit.Like Jacksonville, Oakland is looked at as a rising team. It has one of the leagues best defensive players in Khalil Mack, and the offense should be balanced. Can the secondary slow Brees?Cincinnati at the New York JetsThe first game in a very tough opening stretch for the Jets, who face five 2015 playoff clubs in six weeks. Their front line on D is as good as any in football, but their O-line is questionable. Adding Matt Forte to the backfield should help in the short term.Cincinnati has never won in the Meadowlands: 0-9 vs. the Jets, 0-3 vs. the Giants. The defense is formidable, too, and QB Andy Dalton is back healthy. He will be without dangerous TE Tyler Eifert.Buffalo at BaltimoreTroubled Buffalo has been hit by suspensions and injuries already.We dont want to major in putting hurdles out there, coach Rex Ryan said during training camp. But we seem to be doing a pretty good job of it right now.The Ravens 2015 was ruined by injuries, and most of the key players who were sidelined -- Joe Flacco, Terrell Suggs, Justin Forsett, Steve Smith -- are ready.Los Angeles at San Francisco, Monday nightLos Angeles is back in the NFL for the first time since 1994, though the Rams dont play at home until next week. Top overall draftee Jared Goff is the backup quarterback to Case Keenum for now.Seemingly the focal point for most people watching the 49ers is Colin Kaepernick not standing for the national anthem. Whether he does or not, Chip Kelly debuts as San Franciscos coach.Cleveland at PhiladelphiaWhile Goff sits, the guy taken after him in April, Carson Wentz was handed the Eagles job behind center. Wentz hasnt played since the preseason opener when he broke some ribs.The Browns brought in Robert Griffin III, hoping he can resurrect his QB career after it fell apart in Washington. New coach Hue Jackson works well with the position.Chicago at HoustonThree-time Defensive Player of the Year J.J. Watt comes off two offseason procedures on his back. Not having him at full strength could undermine Houstons defense of the AFC South title, but Watt expects to play -- and play well -- on Sunday.With Matt Forte gone, it will be intriguing to see what the Bears running game looks like.Tampa Bay at AtlantaSome have pegged the Bucs as a rising team, and they have the offense to be dangerous behind Jameis Winston, Doug Martin and Mike Evans. Is their pass rush upgraded enough.Atlanta looked dynamic in going 5-0 and 6-2 before fading to 8-8. Although coach Dan Quinn has a solid defensive background, the Falcons were last with 19 sacks in 2015 and must improve that -- immediately.Detroit at IndianapolisThe Lions have one victory in Indianapolis. In 1991. But their coach, Jim Caldwell, led the Colts to the Super Bowl in 2009. Longtime standout WR Calvin Johnson has retired, a Megatron-size hole Detroit must fill.Colts QB Andrew Luck is expected to make his first regular-season start since Nov. 8, when his injury-ravaged season ended.---AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL http://www.jetsrookiestore.com/Jets-Dennis-Byrd-Jersey/ . Nathan MacKinnon, Jamie McGinn and Jan Hejda also scored for the Avalanche, who won despite being outshot 38-23. MacKinnons goal, also on the power play, came with just over a minute remaining. http://www.jetsrookiestore.com/Jets-Juston-Burris-Jersey/ . -- The Portland Timbers and Real Salt Lake played to a 0-0 tie Saturday night that left the top of the Western Conference standings unchanged. http://www.jetsrookiestore.com/ . Pence singled in the winning run with no outs in the ninth inning to give the Giants a 7-6 victory over the San Diego Padres on Sunday. http://www.jetsrookiestore.com/Jets-Brent-Qvale-Jersey/ . The visitors took a deserved lead in the 16th minute with midfielder Yohan Cabaye curling the ball beyond Adrian from inside the penalty area. http://www.jetsrookiestore.com/Jets-Ardarius-Stewart-Jersey/ . The International Olympic Committee released the official list of bid cities on Friday after the deadline for applications had passed. The candidates -- all previously announced in their own countries -- are: Almaty, Kazakhstan; Beijing; Krakow, Poland; Lviv, Ukraine; Oslo, Norway; and Stockholm. Nico Rosberg said his clean sweep of practice sessions in Suzuka helped him beat Lewis Hamilton to pole position for the Japanese Grand Prix by just 0.013s.Rosberg has been the quickest Mercedes all weekend and topped Hamilton in Q1 and Q2, only for the reigning world champion to edge ahead in the initial Q3 laps. On the final runs Rosberg just did enough to get ahead on a 1:30.647 which Hamilton was unable to match.Reflecting on the lap, Rosberg said: Of course, happy with the result in the end. It was going well the whole weekend and I had a good balance in the car, feeling good, feeling comfortable, and thats what allows me to put in a lap like that in the end.It was just a good lap, just got it all done properly, thats it. I knew I could do it, I knew I could do a good lap. The first one in Q3 wasnt perfect so I just had to get my head down and nail it.Its Rossbergs third consecutive pole position at the Suzuka circuit, though Hamilton beat him to victory from second on the grid in 2014 and 2015.ddddddddddddRosberg knows the start - where Hamilton barged past him last year - will be key, but the German is also wary about the role tyres will play over the course of the race.Its just putting everything together. For sure the start is going to be an important one tomorrow, and weve seen this weekend its not been too easy because its downhill and the grip somehow has been a bit lower than usual - so its going to be an interesting challenge.From then on just need to get the tyre life to get to do long enough stints and everything to get the strategy to work, its just putting everything together. 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